From: "jacqueline strax"
To:
Sent: Sunday, December 06, 2009 2:59 AM
Subject: [PPML] Serial biopsies are associated with an increased risk of ED
in men with prostate cancer on active surveillance.


>J Urol. 2009 Dec;182(6):2664-9.
>
> Serial prostate biopsies are associated with an increased risk of erectile
> dysfunction in men with prostate cancer on active surveillance.
>
> Fujita K, Landis P, McNeil BK, Pavlovich CP.
>
> Brady Urological Institute, The Johns Hopkins University, Baltimore,
> Maryland 21224, USA.
>
> PURPOSE: We determined whether serial prostate needle biopsies predispose
> men to erectile dysfunction and/or lower urinary tract symptoms over time.
> MATERIALS AND METHODS: Men with prostate cancer on an active surveillance
> protocol were administered the 5-item Sexual Health Inventory for Men and
> International Prostate Symptom Score questionnaires on protocol entry, and
> at a cross-sectional point in 2008. All men had at least 1, 10 to 12-core
> prostate biopsy at protocol entry and yearly surveillance biopsies
> thereafter were recommended. RESULTS: Of 333 men 231 returned the followup
> questionnaires. Correlations were found between biopsy number and erectile
> dysfunction, with increasing biopsy number associated with a decrease in
> Sexual Health Inventory for Men score (p = 0.04) and a history of 3 or
> more biopsies associated with a greater decrease in Sexual Health
> Inventory for Men score than after 2 or fewer biopsies (p = 0.02).
> Multivariable analysis for biopsy number, age, prostate volume and
> prostate specific antigen showed that only biopsy number was associated
> with decreasing Sexual Health Inventory for Men score (p = 0.02). When men
> were stratified by baseline Sexual Health Inventory for Men, those without
> preexisting erectile dysfunction (Sexual Health Inventory for Men score 22
> to 25) trended toward steeper decreases in Sexual Health Inventory for Men
> score after 3 or more biopsies (p = 0.06) than did men with baseline mild
> to moderate erectile dysfunction (Sexual Health Inventory for Men score 8
> to 21). No correlation was found between biopsy number and International
> Prostate Symptom Score. CONCLUSIONS: Serial prostate biopsies appear to
> have an adverse effect on erectile function in men with prostate cancer on
> active surveillance but do not affect lower urinary tract symptoms.
>
> best
> Jacquie Strax
> http://www.psa-rising.com
>